New Spectrophotometric Methods for Simultaneous Determination of Amlodipine besylate and Lisinopril in Tablet Dosage Forms.
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Date
2011-08
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Abstract
Two simple, accurate, precise, reproducible, requiring no prior separation and
economical procedures for simultaneous estimation of Amlodipine besylate (AML) and Lisinopril
(LIS) in tablet dosage form have been developed. First method is simultaneous equation method;
in this method 360.0 nm and 248.0 nm were selected to measure the absorbance of drugs at both
wavelengths. The second method is Q-value analysis based on measurement of absorptivity at
300.0 nm (as an iso-absorptive point) and 360.0 nm. AMD and LIS at maximum wavelength of
AML, 360.0 nm and at isoabsorptive point 300.0 nm shows linearity in a concentration range of 5-
40 μg/mL. Recovery studies range from >99.82% for AMD and >98.09% for LIS in case of
simultaneous equation method and >100% for AMD and >98.45% for LIS in case of Q-analysis
method confirming the accuracy of the proposed method. The proposed methods are
recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific
(no heating and no organic solvent extraction is required).
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Keywords
Lisinopril (LIS), Amlodipine besylate (AML), Methanol, UV Spectrophotometer
Citation
Joshi H V, Patel J K. New Spectrophotometric Methods for Simultaneous Determination of Amlodipine besylate and Lisinopril in Tablet Dosage Forms. Journal of Applied Pharmaceutical Science. 2011 Aug; 1(6): 162-164.