Cardioprotective, antioxidant activities and Phytochemical analysis by GC-MS of Gmelina arborea (GA) in Doxorubicin-induced myocardial necrosis in Albino rats.
Loading...
Date
2011-07
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Doxorubicin (DOX) is a widely used cancer chemotherapeutic agent. However, it
generates free oxygen radicals that result in serious dose-limiting cardiotoxicity.
Supplementations with Gmelina arborea (Verbenaceae) were proven effective in reducing
oxidative stress associated with several ailments. The aim of the current study was to investigate
the potential protective effect of Gmelina arborea (GA) against DOX- induced cardiotoxicity in
rats. GA was given orally to rats(250&500mg/kg) and DOX (20mg/kg) was administered on the
seventh day. GA protected against DOX-induced increased the levels of marker enzymes. It
significantly inhibited DOX-provoked glutathione (GSH) depletion in cardiac tissues. The
reductions of cardiac activities of catalase (CAT) ,superoxide dismutase (SOD) ,glutathione
peroxidase (GSH-Px) and glutathione reductase (GR) were significantly mitigated. Pretreatment
of GA significantly guarded against DOX-induced rise of serum lactate dehydrogenase (LDH).
GA alleviated histopathological changes in rats’ hearts treated with DOX. In conclusion, GA
protects against DOX-induced cardiotoxicity in rats. The study can be attributed, at least in part,
to GA’s antioxidant activity.
Description
Keywords
Cardiotoxicity, Doxorubicin, antioxidant, Gmelina arbore, histopathological changes
Citation
Vijay T, Rajan M S Dhana, Sarumathy K, Palani S, Sakthivel K. Cardioprotective, antioxidant activities and Phytochemical analysis by GC-MS of Gmelina arborea (GA) in Doxorubicin-induced myocardial necrosis in Albino rats. Journal of Applied Pharmaceutical Science. 2011 July; 1(5): 198-204.