Enhancement of dissolution rate of etoricoxib through solid dispersion technique.
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Date
2011-07
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Abstract
Etoricoxib, a non-steroidal anti-inflammatory drug, is used to Osteoarthritis, Rheumatoid
arthritis and Acute Gouty arthritis. Etoricoxib is practically insoluble in water; hence present study
was carried out to enhance dissolution properties of Etoricoxib through the preparation of Solid
Dispersions using PEG 6000 as carrier at various proportions by using different techniques like
Physical mixtures, Kneading Method and Solvent Evaporation Method. The drug release profile
was studied in 0.1N HCl containing 1 % SLS. U.V. Spectrophotometric method was selected for
assay as well as in-vitro dissolution studies at 234nm.All the solid dispersions exhibited superior
dissolution than pure drug. The drug dissolution studies followed first order kinetics. Solvent
evaporation method was found to be superior to other methods.
Description
Keywords
Solid dispersion, Etoricoxib, Physical mixtures, Kneading method, Solvent evaporation method
Citation
Muralidhar S, Rao G Devala, Murthy M.Krishna, Kumar K Kiran, Teja K Kranthi, Nawaj Syed Khaja, Narayana T V. Enhancement of dissolution rate of etoricoxib through solid dispersion technique. Journal of Applied Pharmaceutical Science. 2011 July; 1(5): 129-132.