Functionalization and evaluation of PEGylated Carbon Nanotubes as novel Drug delivery for methotrexate.
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Date
2011-07
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Abstract
Several delivery systems are developed to target methotrexate to cancer tissues with
limited success due to low drug loading, size control, toxicity, and scale up and also the cost of
formulation. Off late, carbon nanotubes have been projected as a promising carrier for many drugs
including anticancer agents. The present work is an attempt to investigate the potentialities of
multi-walled carbon nanotubes (MWCNT) as a carrier for targeting methotrexate to cancer
tissues. MWCNTs were functionalized using DSPE-mPEG 2000 and was then reacted with
methotrexate (MTX) to produce MWCNT-mPEG-MTX conjugate. The conjugate was
characterized for particle size, loading efficiency, morphology & rate of drug release. The result
indicated that about 2.26 mg of Methotrexate per mg of MWCNTs were loaded with 56.5%
entrapment efficiency. Particle size of the MWCNT conjugate was found to be less than 200nm
with polydispersity index of 0.286 post lyophilization of the product. The MWCNT conjugate
was found to release the drug faster in acidic medium than at neutral pH. However, in both neutral
and acidic media, the release was continuous over the period of 48 hours.
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Keywords
Multiwalled Carbon Nanotubes, Methotrexate, DSPE-mPEG, Non-Covalent
Citation
Modi Chetana D, Patel Suketu J, Desai Alpesh B, Murthy R S R. Functionalization and evaluation of PEGylated Carbon Nanotubes as novel Drug delivery for methotrexate. Journal of Applied Pharmaceutical Science. 2011 July; 1(5): 103-108.