A validated stability indicating HPLC method for the determination of Valsartan in tablet dosage forms.
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Date
2011-06
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Abstract
A simple, specific, rapid, precise and robust HPLC method has been developed for the
quantitation of valsartan in tablet dosage form on a C18 column (250 x 4.6 mm) using a mobile
phase consisting of ammonium dihydrogen phosphate buffer : methanol (33.5:66.5) adjusted to pH
3 with formic acid at a flow rate of 1.0 ml/min and detection at 265 nm. The retention time of
valsartan was found to be at 11.9 min. The validation of above method was also done. Percentage
label claim of the tablet formulations were found to be 100.8%. So the proposed method provides a
faster and cost effective quality control tool for routine analysis of valsartan from formulations.
Description
Keywords
Valsartan, HPLC, ammonium dihydrogen phosphate buffer, methanol, validation
Citation
Parambi Della Grace Thomas, Mathew Molly, Ganesan V. A validated stability indicating HPLC method for the determination of Valsartan in tablet dosage forms. Journal of Applied Pharmaceutical Science. 2011 Jun; 1(4): 97-99.