Formulation and evaluation of fast dissolving tablets of Granisetron hydrochloride by vacuum drying technique.
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Date
2011-06
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Abstract
The purpose of this investigation was to develop fast dissolving tablets
(FDTs) of Granisetron hydrochloride (GHCl) by vacuum drying technique using camphor as
subliming agent together with croscarmellose sodium (CCS), crospovidone (CP), sodium starch
glycolate (SSG) and plantago ovate (PO) as superdisintegrants. The prepared formulations
were evaluated for pre-compressional and post-compressional parameters. The compatibility of
drug with other ingredients was checked by FTIR studies, the results revealed that there was no
interaction between dug and other excipients. The values of pre-compressional parameters were
within prescribed limits and indicated good free flowing properties. In all the formulations the
hardness test indicates good mechanical strength. Friability of all formulations was less than 1.
Drug content was found to be high (≥ 100.44%) and uniform in all the formulations. The tablet
thickness was found to be 3.11 – 3.34. The weight variation results revealed that average
percentage deviation was less then ± 7.5 %, which provides good uniformity in all
formulations. The disintegration time of the tablets found to be in the range of 18 to 44 sec. The
formulations SBC4, SBP4, SBG4, and SBO4 50 % of drug released in 0.41, 0.48, 0.59 and 0.47
min, and 90 % of drug released in 2.01, 3.05, 4.01 and 2.51min. Stability study carried out as
per ICH guidelines for three months and results revealed that upon storage disintegration time
of tablets decreased significantly (p<0.05). The release of drug from the SBC4 and SBO4
formulations was quick when compared to other formulations. It was concluded that fast
dissolving tablets with improved Granisetron hydrochloride dissolution could be prepared by
sublimation of tablets containing suitable subliming agent.
Description
Keywords
Fast dissolving tablet, Granisetron hydrochloride, Subliming agent, super disintegrant, Camphor
Citation
Patil Basawaraj S, Rao N G Raghavendra. Formulation and evaluation of fast dissolving tablets of Granisetron hydrochloride by vacuum drying technique. Journal of Applied Pharmaceutical Science. 2011 Jun; 1(4): 83-88.