Formulation and evaluation of transdermal patches and to study permeation enhancement effect of eugenol.
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Date
2011-05
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Abstract
Since oral bioavailability of Propranolol Hydrochloride is poor due to high first pass
metabolism different matrix- type transdermal patches incorporating Propranolol Hydrochloride
were formulated with an objective to study the effect of polymers on transdermal release of the
drugs. The polymers selected for sustaining the release of drug were polyvinylpyrrolidone,
Hydroxypropylmethycellulose (HPMC) and Ethyl cellulose (EC). The patches were formulated
using combination of polymers and propylene glycol as plasticizer. The physicochemical
evaluation of the polymer matrices was performed for suitability. In vitro permeation studies
were performed using rat abdominal skin as the permeating membrane in Franz diffusion cell.
The result indicated that maximum release was obtained at 2% solution of EC. Optimized batch
was evaluated for permeation enhancement through rat skin using natural permeation enhancer
Eugenol and it was concluded that permeation enhancement through Eugenol was comparable to
the commercially available permeation enhancer Dimethyl sulfoxide 1% (DMSO). All the films
were found to be stable at 37ºC and 45ºC with respect to their physical parameters and drug
content.
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Keywords
Transdermal patches, Propranolol Hydrochloride, Polyvinylpyrrolidone, Hydroxypropylmethycellulose (HPMC), Ethyl cellulose
Citation
Sheth Nirav S, Mistry Rajan B. Formulation and evaluation of transdermal patches and to study permeation enhancement effect of eugenol. Journal of Applied Pharmaceutical Science. 2011 May; 1(3): 96-101.