Development and evaluation of Meloxicam solid dispersion loaded buccal patches.
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Date
2011-05
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Abstract
Meloxicam, a non-steroidal anti-inflammatory drug is widely used in the treatment
of rheumatoid arthritis, ankylosing spondulytis and osteoarthritis. It is also indicated for the
management of dental pain, Post-traumatic and post-operative pain, inflammation and
swelling. Recently it is considered as a potential drug for prevention and treatment of
colorectal polyps. One of the major problems with this drug is its low solubility in biological
fluids, which results into poor bioavailability and GI-Side effects after oral administration.
The present work was aimed at overcoming these limitations of the drug. The first problem
i.e. Poor solubility of meloxicam was overcome by solid dispersion technique and the same
was than published in a reputed online journal. The present study was the continuation of the
published work, in this study buccal patches were prepared using varying percentage of
carbopol 934p, chitosan (mucoadhesive polymers) and 50% W/W of propylene glycol
(Plasticizer) by solvent casting technique, using 32 factorial design. Prepared blank buccal
patches were evaluated for various physical and mechanical parameters, patches which
comply with reported results were selected for meloxicam and its solid dispersion
incorporation. Meloxicam solid dispersion incorporated buccal patches were prepared and
evaluated for drug content, in-vitro diffusion, in-vivo release of meloxicam in rabbits and
stability study. All solid dispersion loaded patches showed increased in-vitro drug release (i.e.
between 95% to 99.95%) over an extended period of 8hrs as compared to plain drug loaded
buccal patch. Whereas plain drug loaded buccal patch showed only 31.22% in-vitro drug
release in 8hrs. Meloxicam solid dispersion loaded buccal patch (MSP1) containing
meloxicam solid dispersion (meloxicam 150mg, PVP250mg, PEG6000 175mg and mixture
of lactose and MCC(4:1)4gm) equivalent to 7.5mg of meloxicam, 1.5% of carbopol 934p, 2%
of chitosan and 50% of polymer weight of propylene glycol in each 1cm2 of the patch showed
highest in-vitro drug release i.e. 99.95% in 8hrs and it followed zero order release(r=0.9961,
a=8.3124, b=5.0668). The r, a and b are correlation coefficient, slope and constant
respectively for the best fit kinetic model. The in-vivo release of meloxicam from its solid
dispersion loaded buccal patches was also studied using rabbit model. A good in-vitro in-vivo
correlation was observed in MSP1 patch. All solid dispersion loaded buccal patches showed
excellent stability under tested conditions. Finally it may be concluded that buccal patches
were better for improvement of release of meloxicam and also to overcome the gastric side
effects of drug.
Description
Keywords
Meloxicam, Solid dispersion, Buccal Patch, In-vitro release, In-vivo release
Citation
Jafar Mohammed, Ali Sadath. Development and evaluation of Meloxicam solid dispersion loaded buccal patches. Journal of Applied Pharmaceutical Science. 2011 May; 1(3): 77-82.