Iontophoretic drug delivery: History and applications.
Loading...
Date
2011-05
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The goal of delivery system is to get optimal therapeutic management. But, it still
remains a challenge in the field of pharmaceuticals for delivery of ionic species and some non
ionic. Several transdermal approaches have been used and recently there has been a great attention
in using iontophoretic technique for the transdermal drug delivery of medications, both ionic and
non ionic. This technique of facilitated movement of ions across a membrane under the influence
of an externally applied electric potential difference is one of the most promising physical skin
penetrations enhancing method. The payback of using iontophoretic technique includes improved
systemic bioavailability ensuing from bypassing the first metabolism. Variables due to oral
administration, such as pH, the presence of food or enzymes and transit times can all be
eliminated. This article is an overview of the history of iontophoresis, mechanism, principles and
factors influencing iontophoresis and its application for various dermatological conditions.
Description
Keywords
Iontophoresis, Penetration, skin, Topical drug delivery, Transdermal drug delivery etc
Citation
Khan Azad, Yasir Mohd, Asif Mohd, Chauhan Iti, Singh Alok P, Sharma Rajat, Singh Pradeep, Rai Shubham. Iontophoretic drug delivery: History and applications. Journal of Applied Pharmaceutical Science. 2011 May; 1(3): 11-24.