Investigation of in-vitro anthelmintic activity of Bauhinia racemosa linn.
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Date
2011-04
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Abstract
Helminth infections are the most common health problems in India, in developing
countries they pose a large treat to public. These infections can affect most population in endemic
areas with major economic and social consequences. The plant Bauhinia Racemosa Linn. is a
species of flowering plant belongs to Fabaceae family. The different parts of plant being
traditionally used in catarrh, infection of children, boil, glandular and swelling. The present study
was undertaken to evaluate anthelmintic activity of different extracts of whole plant of Bauhinia
Racemosa Linn. The different successive extracts namely petroleum ether, ethanol and aqueous
using an adult Indian earthworms, Pheretima posthuma as a test worm. Three concentrations (50,
75 and 100 mg/ml) of each extracts were studied in the bioassay which involved the determination of
time of paralysis and time of death of the worm. Albenzadole in same concentration as that of extract
was included as standard reference and normal saline water as control. The results of present study
indicate that the crude ethanolic extract significantly demonstrated paralysis and also caused death of
worm in dose dependent manner, while aqueous and petroleum extracts show weak anthelmintic
effect. Further studies are in process to isolate the active principles responsible for the activity.
Description
Keywords
Bauhinia Racemosa, Anthelmintic activity, Pheretima Posthuma, Albenzadole
Citation
Kumar Tekeshwar, Alexander Amit, Ajazuddin, Dewangan Dhansay, Khan Junaid, Sharma Mukesh. Investigation of in-vitro anthelmintic activity of Bauhinia racemosa linn. Journal of Applied Pharmaceutical Science. 2011 Apr; 1(2): 73-75.