Anti-ulcerogenic potential of ficus bengalensis leaf, biochemical parameter & histopathological study.
Loading...
Date
2011-04
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The effect of aqueous extract of Ficus bengalensis (FBE) was assessed in different acute and
chronic gastric ulcer models in rats. Gastric ulcers induced in swiss albino rats (200g, N=6) by oral
administration of aspirin suspension and pylorus ligation. The anti ulcer activity was assessed by
determining and comparing the ulcer index in the test drug groups with that of the vehicle control
and standard ranitidine & sucralfate. FBE, 250–500 mg/kg administered orally, twice daily for 5
days showed dose-dependent ulcer protective effect in pylorus ligation (51.28, 63.24% protection,
P < 0.01 to P < 0.001), aspirin (28.94, 64.91 protection, P < 0.001). The parameters taken to
assess antiulcer activity were pH of gastric juice, total acidity and ulcer index. The results
indicated that aqueous extract significantly (p<0.05) Ph, total acidity and ulcer index. On the basis
of histopathology analysis, The results indicate that FBE possesses antiulcer activity in a dose
dependent manner.
Description
Keywords
Ficus bengalensis, Pylorus ligation, Acidity, Ulcer index
Citation
Kulshreshtha Mayank, Goswami Mradul, Rao Chandana V, Ashwlayan Vrish D, Yadav Sachdev. Anti-ulcerogenic potential of ficus bengalensis leaf, biochemical parameter & histopathological study. Journal of Applied Pharmaceutical Science. 2011 Apr; 1(2): 65-68.