Study of biochemical markers in iron deficiency anemia.
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Date
2013-10
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Abstract
Background: The present study was aimed to study alterations in levels of oxidants and antioxidants in iron deficiency anemia (IDA).
Methods: 30 patients of IDA in age group of 20-50 and 30 healthy subjects were included for study. Serum Iron, TIBC & Hb% were estimated to diagnose IDA. Serum Malondialdehyde (MDA), Nitric oxide (NO) as an oxidants & Superoxide dismutase (SOD), vitamin E, vitamin C, Zinc (Zn) levels as antioxidants were estimated.
Results: Significant decreased levels of Hb%, serum iron, SOD, Vitamin C, vitamin E, Zn were found. TIBC, MDA, NO were significantly increased as compared to controls.
Conclusion: The normal adult erythrocytes can resist oxidative stress by several antioxidant defense systems. In IDA, oxidative stress causes lipid peroxidation and membrane damage. So antioxidants can be used as a marker for prevention of membrane damage due to oxidative stress.
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Keywords
Oxidants, Antioxidants, IDA (Iron Deficiency Anemia)
Citation
Deokar Smita A, Rai Pooja S K, Bakshi Amruta A, Rai Anita B. Study of biochemical markers in iron deficiency anemia. International Journal of Research in Medical Sciences. 2013 Oct-Dec; 1(4): 541-544.