Formulation and evaluation of esomeprazole magnesium dihydrate multiple unit particulate system ( pellets) as a delayed release dosage form.
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Date
2014-02
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Abstract
The present study was an attempt to formulate and evaluate enteric coated tablets for Esomeprazole magnesium dihydrate delayed release multiparticulate
to reduce the Gastrointestinal tract side effects.The delayed release multiple units were prepared by using fluid-bed werster technology.These multiple
units are selected by seal coating, drug coating and enteric coating.These Esomeprazole magnesium dehydrate were evaluated for assay, acid resistence, drug
release,dissolution, Kinetic studies of Innovator and Optimized formulation, Stability studies of Optimized formulation. This study concluded Esomeprazole
magnesium dihydrate can be prepared by using combination of polymers studied and we can reduce the GI tract side effects.
Description
Keywords
Esomeprazole magnesium dehydrates, proton pump inhibitor, fluid-bed technique
Citation
Naik R Nagarjuna, Potti Laksmano Rao, Mogali Rama Kotaiah, Rao M Prasad, Sivasankar R, valli Beera. Formulation and evaluation of esomeprazole magnesium dihydrate multiple unit particulate system ( pellets) as a delayed release dosage form. International Journal of Research and Development in Pharmacy and Life Sciences. 2014 Feb-Mar; 3(2): 935-942.