Influence of ethanol-induced pulmonary embolism on hemodynamics in pigs.
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Date
2013-10
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Abstract
Aims and Objectives: Ethanol is widely used for the embolization treatment of vascular malformations, but
it can also cause serious complications such us pulmonary hypertension, cardiopulmonary collapse and
death. The complications are considered secondary to pulmonary vasospasm and ethanol‑induced sludge
embolism, etc., We studied the hemodynamic effects of intravenous absolute ethanol injection and ethanol
sludge injection in pigs. Materials and Methods: A total of 5 pigs underwent intravenous injection of ex vivo
generated ethanol‑induced sludge in which residual ethanol was removed (Group S) and 4 pigs underwent
intravenous injection of absolute ethanol (Group E). Hemodynamic parameters related to the pulmonary and
systemic circulation were compared between the groups. Results: Transient pulmonary hypertension was
observed in both groups and the hemodynamic changes were similar in both groups. Conclusions: Sludge
can induce transient pulmonary hypertension or cardiopulmonary collapse, without ethanol and may be the
mechanism by which ethanol induces its adverse hemodynamic effects.
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Keywords
Cardiopulmonary collapse, Ethanol, Pulmonary hypertension
Citation
Yata Shinsaku, Hashimoto Masayuki, Kaminou Toshio, Ohuchi Yasufumi, Sugiura Kimihiko, Adachi Akira, Kawai Tsuyoshi, Endo Masayuki, Takasugi Shohei, Yamamoto Shuichi, Matsumoto Kensuke, Kodani Mika, Ihaya Takashi, Takahashi Makoto, Ito Hisao, Ogawa Toshihide. Influence of ethanol-induced pulmonary embolism on hemodynamics in pigs. Annals of Cardiac Anaesthesia. 2013 Oct; 16(4): 245-249.