The association of plasminogen activator inhibitor-1 level with ischemic stroke (preliminary study).
Loading...
Date
2010-08
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Aim Recently, increased plasminogen activator inhibitor-1 (PAI-1) has been known a risk factor for ischemic heart disease. However, the association of increased PAI-1 level with ischemic stroke remains unclear. The aim of this study was to analyze the association of PAI-1 level with ischemic stroke.
Methods By case control design we involved 38 ischemic stroke and 38 risky-matched control subjects who fulfilled the criteria. The PAI-1 level was determined by ELISA method using Asserachrom PAI-1 from Stago.
Results High PAI-1 level was found more frequent in ischemic stroke subjects than in control subjects (21.1% vs. 7.9 % with OR 3.1; 95 % CI 0.757 – 12.790). The analysis of all studied subjects showed that there was a weak negative correlation between PAI-1 level and age (r = -0.4; P = 0.000). High PAI-1 level was found more frequent in younger (40 – 58 years old) than in the older subjects (60 – 84 years old) (20% vs. 9.8 %) (p=0.004).
Conclusion The result of this preliminary study suggested an association between PAI-1 level and ischemic stroke in younger age. Further study with larger subjects is recommended to confirm this association.
Description
Keywords
ischemic stroke, plasminogen activator inhibitor-1, stroke risk factors
Citation
Surjawan Yenny, Setiabudy Rahajuningsih D, Suryaatmadja Marzuki, Ranakusuma Teguh A S. The association of plasminogen activator inhibitor-1 level with ischemic stroke (preliminary study). Medical Journal of Indonesia. 2010 Aug; 19(3): 158-164.