Evaluation of total soluble solids content (TSSC) and endogenous pH in antimicrobials of pediatric use.
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Date
2013-07
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Abstract
Background: The use of liquid pharmaceutical preparations is a daily occurrence for some
children. Evidences show a significant relation between the intake of oral sucrose based
medicines and an increase incidence in dental caries.
Aim: This in vitro experimental study evaluated the Total Soluble Solids Content (TSSC) by
means of Brix scale refractometry and the endogenous pH of antimicrobials of pediatric use
presented as oral suspensions.
Materials and Methods: Nine medications (6 chemotherapics and 3 antibiotics) were evaluated
by random experiment with 3 repetitions for each sample. The analysis of TSSC readings
were performed by Brix refractometry using the Abbé refractometer, and the pH values were
determined by potentiometry.
Results: The mean TSS contents ranged from 11.73 (Keflaxina) to 63.83 (Azitromed). The
minimum and maximum mean pH values were 4.12 (Keflaxina) and 10.97 (Zitroneo), respectively.
Conclusions: The chemotherapic antimicrobials evaluated in this study presented the highest
TSSC means, while the antibiotics showed pHs below the values considered as critical, which
may contribute to the development of caries lesions in case of inadequate administration of
these medications to children.
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Keywords
Administration, oral, pediatrics, pharmaceutical preparations, total solids
Citation
Cavalcanti Alessandro Leite, Oliveira Klélia Forte de, Xavier Alidianne F C, Pinto Daiane S C, Vieira Fernando Fernandes. Evaluation of total soluble solids content (TSSC) and endogenous pH in antimicrobials of pediatric use. Indian Journal of Dental Research. 2013 Jul-Aug; 24(4): 498-501.