Clinico-pathological impact of cytogenetic subgroups in B-cell chronic lymphocytic leukemia: Experience from India.
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Date
2013-07
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Abstract
BACKGROUND: The present study of 238 B‑cell Chronic Lymphocytic Leukemia (B‑CLL) patients were undertaken
to seek the prevalence and to evaluate clinico‑pathological significance of recurrent genetic abnormalities such as
del(13q14.3), trisomy 12, del(11q22.3) (ATM), TP53 deletion, del(6q21) and IgH translocation/deletion. MATERIALS AND
METHODS: We applied interphase – fluorescence in situ hybridization (FISH) on total 238 cases of B‑CLL. RESULTS:
Our study disclosed 69% of patients with genetic aberrations such as 13q deletion (63%), trisomy 12 (28%), 11q
deletion (18%), 6q21 deletion (11%) with comparatively higher frequency of TP53 deletion (22%). Deletion 13q displayed
as a most frequent sole abnormality. In group with coexistence of ≥2 aberrations, 13q deletion was a major clone
indicating del(13q) as a primary event followed by 11q deletion, TP53 deletion, trisomy 12, 6q deletion as secondary
progressive events. In comparison with del(13q), trisomy 12, group with coexistence of ≥2 aberrations associated
with poor risk factors such as hyperleukocytosis, advanced stage, and multiple nodes involvement. In a separate study
of 116 patients, analysis of IgH abnormalities revealed either partial deletion (24%) or translocation (5%) and were
associated with del(13q), trisomy 12, TP53 and ATM deletion. Two of 7 cases had t(14;18), one case had t(8;14), and
four cases had other variant IgH translocation t(?;14). CONCLUSION: Detail characterization and clinical impact are
necessary to ensure that IgH translocation positive CLL is a distinct pathological entity. Our data suggests that CLL
with various cytogenetic subsets, group with coexistence of ≥2 aberrations seems to be a complex cytogenetic subset,
needs more attention to understand biological significance and to seek clinical impact for better management of disease.
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Keywords
B‑cell chronic lymphocytic leukemia, fluorescence in situ hybridization, group with coexistence of ≥2 aberrations, IgH aberrations, clinical impact
Citation
Kadam Amare P S, Gadage V, Jain H, Nikalje S, Manju S, Mittal N, Gujral S, Nair R. Clinico-pathological impact of cytogenetic subgroups in B-cell chronic lymphocytic leukemia: Experience from India. Indian Journal of Cancer. 2013 July-Sept; 50(3): 261-267.