Presence of CD3+ tumor infiltrating lymphocytes is significantly associated with good prognosis in infiltrating ductal carcinoma of breast.
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Date
2013-07
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Abstract
BACKGROUND: Aim of this study was to investigate the prognostic significance of CD3+ TILs in infiltrating ductal carcinoma
(IDC) of the breast. MATERIALS AND METHODS: Immuno-histochemistry was done with CD3 antibodies in tissue sections
of 127 breast cancer patients, and CD3+ intra-tumoral and stromal TILs were counted in relation to clinico-pathological
variables. RESULTS: Intra-tumoral and stromal CD3+ TILs were significantly associated with positive lymph node status
(P = 0.006, P = 0.043, respectively) without significant association with age, menopausal status, family history, and
hormonal status. The higher CD3 intra-tumoral and stromal counts both showed significant association with good prognosis
(P = 0.039, P = 0.044, respectively). The intra-tumoral count was higher than stromal count and was independently associated
with disease-free survival in stage I and II cancer (P = 0.021). CONCLUSIONS: CD3+ TILs may serve as independent
marker of good prognosis in IDC breast. The findings of this study need further validation on a larger sample size.
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Keywords
Breast cancer, CD3, infiltrating ductal carcinoma, intra-tumoral T-cells, stromal T-cells, tumor infiltrating lymphocytes
Citation
Rathore A S, Kumar S, Konwar R, Srivastava A N, Makker A, Goel M M. Presence of CD3+ tumor infiltrating lymphocytes is significantly associated with good prognosis in infiltrating ductal carcinoma of breast. Indian Journal of Cancer. 2013 July-Sept; 50(3): 239-244.