Role of C Reactive Protein as a Rapid Screening Test for the Judicious Use of Antibiotics in Neonatal Sepsis.
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Date
2009-12
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Abstract
Neonatal infections according to WHO cause mortality in 42% of cases out
of which neonatal sepsis is a major cause. C-reactive protein plays a very
important role in screening of neonatal sepsis as it can predict an early
infection. C-reactive protein added to the full clinical picture contributes
usefully to diagnosis, prognosis and management. Sometimes, the
antibiotics have to be given for a longer time but CRP can help in early
discontinuation of antibiotics.
In the present study, 7032 neonates in the age group 0-28 days were
screened, using latex agglutination test kit by Tulip diagnostics. A
concentration of 0.6mg/dl was taken as positive. Negative and positive
controls were always included in the test. The prognosis of a case of sepsis
was judged by repeated estimation of CRP at 48 hours, then 72 hours and
subsequent to the clinical response and effect of antibiotic therapy.
In cases showing CRP more than or equal to 0.6mg/dl, serial doubling
dilutions of patients serum were tested to find out its exact amount. Of
7032 neonates examined, 2707 (38.5%) had CRP level >0.6mg/dl.
Description
Keywords
C reactive protein, sepsis, neonate, infection, antibiotics
Citation
Malhotra V L, Khandpur Neelam, Lakhsmy A , Nagarkar Meenakshi. Role of C Reactive Protein as a Rapid Screening Test for the Judicious Use of Antibiotics in Neonatal Sepsis. Journal of Communicable Diseases. 2009 Dec; 41(4): 275-277.