Attenuation of Serum Ferritin and Iron Burden by Intake of Antioxidants in Beta Thalassemia Major.
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Date
2013-04
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Abstract
It has been anticipated that iron and ferritin burden in patients
with beta thalassemia major is associated with enhanced free radical
formation and blemished antioxidant defense system. The goal of study was
to scrutinize impact of serum iron, total iron binding capacity (TIBC),
ferritin and erythrocyte catalase in patients with beta thalassemia major.
140 beta thalassemia major patients were studied before and after
supplementation of antioxidants for one month, and status was compared
with 140 age and sex matched healthy controls. A significant elevation was
found in the levels of serum iron and ferritin (P<0.001) with concomitant
decrease in erythrocyte catalase (P<0.001) in patients when compared with
controls. After one month supplementation of antioxidants, catalase was
elevated significantly (P<0.001) and marginal rise in serum TIBC
concentration increased marginally while iron and ferritin were decreased
marginally (P>0.05) when compared with controls and baselines values.
Beta thalassemia major children receive multiple blood transfusions, and
are at risk of secondary iron overload induced oxidative stress. These
effects may be help to minimize with supplementation of antioxidants.
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Keywords
beta thalassemia major, serum ferritin, oxidative stress, iron overload
Citation
Bhagat Sonali S, Sarkar Purnima Dey, Suryakar Adinath N, Padalkar Ramchandra K, Ghone Rahul A, Patil Sangita M, Hundekar Prakash S. Attenuation of Serum Ferritin and Iron Burden by Intake of Antioxidants in Beta Thalassemia Major. Indian Journal of Physiology and Pharmacology. 2013 Apr-Jun; 57(2): 189-194.