Association of pattern reversal VEP parameters with the Meandefect of Humphrey visual field in patients of primary open Angleglaucoma.
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Date
2013-04
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Abstract
Glaucoma is a chronic, progressive bilateral optic neuropathy
which disturbs the structural or functional integrity of the optic nerve that
causes characteristic atrophic changes in it, which leads to specific visual
field defects over time with loss of visual function. Primary open angle
glaucoma (POAG) is the most common form of glaucoma in India and is fast
emerging as a major cause of bilateral blindness. This rural hospital based
study was conducted to evaluate whether glaucomatous visual field defects
particularly the mean defect of Humphrey visual field could be related to
VEP parameters of patients having POAG. Visual field by Humphrey
perimeter and simultaneous recordings of pattern reversal visual evoked
potential (PRVEP) were assessed in 100 patients with POAG. There was a
significant (P<0.05) negative correlation of P100 latency, N155 latency and
P100 duration and a highly significant (P<0.001) positive correlation of
P100 amplitude with mean deviation (index of global visual field damage,
MD) of Humphrey visual field in the subjects of POAG in various age
groups. N70 latency showed a non-significant positive correlation with MD.
The VEP changes observed by us in POAG patients were consistent with
the progressing mean defect quantitatively. Therefore, it can be concluded
that the VEP parameters can be useful quantitative indices in the evaluation
of glaucomatous visual function damage.
Description
Keywords
pattern reversal, mean defect, visual field, P100 latency, P100 amplitude
Citation
Kothari Ruchi, Singh Ramji, Singh Smita, Bokariya Pradeep. Association of pattern reversal VEP parameters with the Meandefect of Humphrey visual field in patients of primary open Angleglaucoma. Indian Journal of Physiology and Pharmacology. 2013 Apr-Jun; 57(2): 123-131.