Assessment of Myocardial Mechanics in Overweight and Obese Indian Subjects.
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Date
2013-04
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Abstract
Obesity is associated with increased cardiovascular morbidity
and mortality. A direct effect of isolated obesity on cardiac function is not
well established. The study was designed to determine the direct effect of
various grades of isolated obesity on Echocardiographic indices of systolic
and diastolic left ventricular function. Forty five overweight & obese and
30 normal weight, serving personnel without any other pathological
condition were studied. Group I (n=23) consisted of subjects with normal
weight and body mass index (BMI 18.5-22.9 kg/m2), Group II (n=28) of
overweight subjects (BMI 23-24.9 kg/m2) and Group III (n=24) of obese
subjects (BMI ≥25 kg/m2). Echocardiographic indices of systolic and diastolic
function were obtained and dysfunction was assumed when at least two
values differed by ≥2 SD from the normal weight group. Ejection fraction
was increased (p=0.001) in group II and III however fractional shortening
was increased significantly in group III (<0.001). Left ventricular dimensions
(EDD & ESD) were increased (P<0.001, 0.002) but relative wall thickness
was unchanged in group II & III. Systolic dysfunction was not observed in
any of the obese patients. The deceleration time was increased (P<0.01) in
overweight and obese subjects compared to normal group individuals. No
difference was found between obesity subgroups. Subclinical diastolic
dysfunction in the form of reduced E/A ratio and increased deceleration
time was more prevalent among obese subjects. BMI correlated significantly
with indices of left ventricular systolic and diastolic function. Subclinical
left ventricular diastolic dysfunction was noted in all grades of obesity
which correlates with BMI.
Description
Keywords
obesity, systolic function, diastolic function, echocardiography
Citation
Pandey Anil Kumar, Das Asim, Sreehari Babu M, Himabindu Y, Farha Nazia, Parvati R, Akhade Varsha Vijay. Assessment of Myocardial Mechanics in Overweight and Obese Indian Subjects. Indian Journal of Physiology and Pharmacology. 2013 Apr-Jun; 57(2): 95-103.