Antioxidant, Anti-inflammatory and Antinociceptive Activities of Essential Oil from Ginger.
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Date
2013-01
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Abstract
Chemical compositions of ginger oil as well as its antioxidant,
anti-inflammatory and antinociceptive potential were evaluated in the
present study. The main constituents as detected by GC/MS analysis was
V-zingiberene which constituted 31% of the total area, ar-curcumene (15.4%)
and a -sesquiphellandrene (14.02%). Ginger oil scavenged superoxide, DPPH,
hydroxyl radicals and inhibited tissue lipid peroxidation in vitro .
Intraperitoneal administration of ginger oil was found to inhibit phorbol-
12-myristate-13-acetate induced superoxide radicals elicited by macrophages.
Oral administration of ginger oil for one month, significantly increased
superoxide dismutase, glutathione and glutathione reductase enzymes level
(P<0.001) in blood of mice and glutathione-S-transferase, glutathione
peroxidase and superoxide dismutase enzymes in liver. Ginger oil produced
significant reduction in acute inflammation produced by carrageenan and
dextran and formalin induced chronic inflammation (P<0.001). It also
exhibited significant reduction in acetic acid induced writhing movements
(P<0.001). The present report revealed that ginger oil possesses antioxidant
activity as well as significant anti-inflammatory and antinociceptive property.
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Keywords
antioxidant activity, anti-inflammatory, antinociceptive, essential oil GC/MS
Citation
Jeena Kottarapat, Liju Vijayastelter B, Kuttan Ramadasan. Antioxidant, Anti-inflammatory and Antinociceptive Activities of Essential Oil from Ginger. Indian Journal of Physiology and Pharmacology. 2013 Jan-Mar; 57(1): 51-62.