Association of Obesity and Leptin with Insulin Resistance in Type 2 Diabetes Mellitus in Indian Population.
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Date
2013-01
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Abstract
Obesity and diabetes mellitus are two modern epidemics. But
their interrelationship is debated. Here we explored the probable association
among obesity, leptin and insulin resistance in type 2 diabetes mellitus. 60
recent onset (<5 years) diabetics and age-sex matched 33 non diabetic
controls were assessed for physical and chemical parameters like Body
Mass Index, abdominal circumference, waist/hip ratio, fasting blood glucose,
insulin and leptin. Degree of insulin resistance was calculated by HOMAIR
method (Homeostatic Model Assessment). All the physical parameters
showed positive correlation with leptin and the HOMA-IR score, strength
of association being highest between insulin resistance and abdominal
circumference. Leptin and insulin resistance showed no correlation. Findings
were lower in controls. Study concluded that, obesity mainly central type
might be responsible for insulin resistance in type 2 diabetes mellitus
where as leptin, a potential marker for obesity, may not. This perhaps
points towards the multifactorial causation of insulin resistance in type 2
diabetes mellitus.
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Keywords
leptin, insulin resistance, HOMA-IR, obesity
Citation
Das Piyali, Bhattacharjee Debojyoti, Bandyopadhyay Subir Kumar, Bhattacharya Gorachand, Singh Ramji. Association of Obesity and Leptin with Insulin Resistance in Type 2 Diabetes Mellitus in Indian Population. Indian Journal of Physiology and Pharmacology. 2013 Jan-Mar; 57(1): 45-50.