Effect of thymoquinone on ethanol and high fat diet induced chronic pancreatitis—a dose response study in rats.
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Date
2013-04
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Abstract
A significant increase in serum lipase, amylase, capase-1 and myeloperoxidase activities, oxidative stress index (OSI), IL-1β and IL-18 was observed in rats receiving ethanol (EtOH) and high fat diet (HFD). Thymoquinone (TQ) supplementation along with EtOH and HFD significantly decreased the levels of serum lipase, amylase, capase-1, myeloperoxidase, OSI and maintained the antioxidant status when compared to untreated EtOH and HFD fed rats. Among the 4 doses, 100 mg of TQ/kg body weight was found to provide optimum protective effect on pancreas against EtOH and HFD induced abnormal changes. Histological observations added more evidence for the anti-inflammatory effect of TQ.
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Keywords
Antioxidants, Ethanol, High fat diet, Inflammation, Pancreatitis, Thymoquinone
Citation
Suguna Periyanayagam, Geetha Arumugam, Aruna Ravikumar, Siva Ganesan Vijaiyan. Effect of thymoquinone on ethanol and high fat diet induced chronic pancreatitis—a dose response study in rats. Indian Journal of Experimental Biology. 2013 Apr; 51(4): 292-302.