Sonic hedgehog inhibition induces mouse embryonic stem cells to differentiate toward definitive endoderm.
Loading...
Date
2013-03
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
In the experimental group (shh inhibited group), there were significant decreases in the expression of Oct4, Nanog, Shh, GATA4, Brachyury and Goosecoid, while increases were observed for TAT and Pdx1. The expression of Sox17 did not differ between two control and experimental groups. In experimental group, the amount of GSC positive cells was somehow lower but it seems that there was no difference for Sox17. Shh inhibition induces ESCs to differentiate toward definitive endoderm by committing mesendodermal lineages.
Description
Keywords
Definitive endoderm, Dithizone, Hedgehog interacting protein, Mesendoderm, Mouse embryonic stem cell
Citation
Ghanbari Ali, Khazaei Mozafar, Hashemi-Tabar Mahmoud, Rabzia Arezou, Fathi Fardin, Bayat Parvin-Dokht. Sonic hedgehog inhibition induces mouse embryonic stem cells to differentiate toward definitive endoderm. Indian Journal of Experimental Biology. 2013 Mar; 51(3): 201-207.