Role of insulin resistance and diet in acne.
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Date
2013-05
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Abstract
There is increasing evidence in support of the interplay of growth hormone (GH), insulin, and insulin-like growth factor-1 (IGF-1) signaling during puberty, which have a causal role in pathogenesis of acne by influencing adrenal and gonadal androgen metabolism. Milk consumption and hyperglycemic diets can induce insulin and IGF-1-mediated PI3K ⁄ Akt-activation inducing sebaceous lipogenesis, sebocyte, and keratinocyte proliferation, which can aggravate acne. Occurence of acne as part of various syndromes also provides evidence in favor of correlation between IGF-1 and acne.
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Keywords
Acne pathogenesis, diet, insulin like growth factor 1, insulin resistance
Citation
Kumari Rashmi, Thappa Devinder Mohan. Role of insulin resistance and diet in acne. Indian Journal of Dermatology, Venereology and Leprology. 2013 May-Jun; 79(3): 291-299.