Dyslipidemia and Superoxide Dismutase Activity in Children with Down Syndrome.
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Date
2010-09
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Abstract
Introduction: Down Syndrome (trisomy 21) provides an interesting natural model to study atherosclerosis,
since these individuals appear to be protected from plaque formation. Methodology: We assessed the
lipid levels, and superoxide dismutase (SOD) activity in 32 clinically diagnosed children of Down syndrome
and 34 children matched for age and sex as controls. Results: SOD activity was found to be significantly
higher (p=0.004) in children with Down Syndrome (mean=313.7 IU/ml) than in controls (mean140.2 IU/
ml). Significantly higher levels of serum triglyceride (154.7 mg/dl) and VLDL (33.9 mg/dl) were observed
in Down Syndrome as compared to healthy controls (119.6 mg/dl and 23.9 mg/dl respectively; p<0.05 for
each). However, the two groups did not show any significant difference in levels of serum HDL-C, LDL-C.
Conclusion: The raised antioxidant activity of SOD, because of over expression of genes situated non
chromosome 21, probably offers some protection against the development of atherosclerosis despite the
occurrence of dyslipidemia.
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Keywords
Chromosome 21, Down Syndrome, Trisomy 21, Superoxide dismutase
Citation
Goyal P, Singh R, Yadav A, Dutta A K, Bhattacharjee J. Dyslipidemia and Superoxide Dismutase Activity in Children with Down Syndrome. Journal of Nepal Paediatric Society. 2010 Sept-Dec; 30(3): 160-163.