Is it worth treating Category I failure patients with Category II regimen.
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Date
2005-10
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Abstract
Background: Very little information is available on the drug susceptibility profile among patients who are treated with
standardized short-course chemotherapy regimens under programme conditions.
Methods: Sputum samples were collected from new sputum smear-positive patients declared ‘failure’ after treatment with
Category I regimen under tuberculosis control programme using DOTS strategy from a rural area of Tamil Nadu.
Results: Of 1463 patients started on Category I regimen between May1999 and December 2002, 74 cases were declared
as ‘failures’ (smear positive at 5/6 months of treatment). We collected sputum samples from 60 (81%) of 74 ‘failures’ and
27% (16 of 60) of them were culture-negative for M tuberculosis and 17% (10 of 60) had organisms resistant to Isoniazid
and Rifampicin (MDR TB).
Conclusion: Based on the drug susceptibility profile at the time of ‘failure’, treating Category I ‘failures’ with Category
II regimen with close monitoring appears to be justified.
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Keywords
Tuberculosis, DOTS
Citation
Santha T, Gopi P G, Rajeswari R, Selvakumar N, Subramani R, Chandrasekaran V, Rani B, Thomas A, Narayanan P R. Is it worth treating Category I failure patients with Category II regimen. Indian Journal of Tuberculosis. 2005 Oct; 52(4): 203-206.