Acute Respiratory Distress Syndrome as a paradoxical response to anti-tuberculosis and anti-retroviral therapy.
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Date
2006-07
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Abstract
Paradoxical response or immune reconstitution inflammatory syndrome (IRIS) during the course of antituberculous
therapy is being increasingly recognised among patients with and without HIV co-infection. A 40-year-old
HIV infected male on anti-retroviral therapy (ART) presented with persistent fever and weight loss. He was diagnosed to
have miliary tuberculosis and HIV co-infection. Following initiation of anti-tuberculous chemotherapy, the clinical
course was characterised by development of acute respiratory failure (ARDS) as a paradoxical response/IRIS to treatment.
This uncommon manifestation of paradoxical response (ARDS) in HIV and tuberculous co-infection following initiation
of ART and anti-TB treatment is very scarcely reported in the past. With the increasing incidence of HIV/AIDS and TB
co-infection along with liberal access to ART in the developing world, it is likely that paradoxical reactions will be
encountered more frequently.
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Keywords
Tuberculosis, AIDS, ARDS, Paradoxical response, IRIS, ART, HAART
Citation
Subhash H S, Supriya S, Prakash B, Thomas K. Acute Respiratory Distress Syndrome as a paradoxical response to anti-tuberculosis and anti-retroviral therapy. Indian Journal of Tuberculosis. 2006 Jul; 53(3): 157-160.