Effect of methomyl formulation, a carbamate pesticide on ovarian follicular development and fertility in albino mice.
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Date
2012-01
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Abstract
Administration of 5 mg methomyl (40%) kg-1 b.wt. mouse-1 (equal to 50% of LD50 dose), every day for
90 days to adult female mice resulted in a significant decrease in body weight, relative weight of the
ovary, uterus and fallopian tube; mean number of small, preantral, antral and pre-ovulatory follicles and
fertility compared to controls. On the other hand, total duration of the estrous cycle was significantly
increased compared to controls. One month after the cessation of the treatment (a commercial methomyl
preparation-lannate) the effect on estrous cycle and organ weight was not restored. Treatment of 2.5 mg or
1 mg lannate kg-1 b. wt., although did not alter duration of the estrous cycle; relative weight of the ovary,
uterus, and fallopian tube and fertility, caused a significant decrease in mean number of small follicles
compared to controls. All the groups of mice treated with lannate showed loss in body weight (15.15%
in 1 mg, 6.61% in 2 mg and 12.16% in 5 mg treated groups) whereas controls showed a gain in body
weight (20.02%) during the period of experimentation. The results indicate that 5 mg lannate kg-1 b. wt.
causes loss of follicles and infertility, whereas lower dosages (2.5 and 1 mg) reduce the number of small
follicles which might shorten reproductive life span of mice.
Description
Keywords
Carbamate pesticide, Fertility, Follicular development, Lannate, Methomyl, Mice
Citation
Shanthalatha A, Madhuranath B N, Yajurvedi H N. Effect of methomyl formulation, a carbamate pesticide on ovarian follicular development and fertility in albino mice. Journal of Environmental Biology. 2012 Jan; 33(1): 33-37.