Antioxidant and hepatoprotective activity of an ethanol extract of piper cubeba fruits.
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Date
2013-02
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Abstract
The fruits of the Piper cubeba plant were chosen and studied for antioxidant and hepatoprotective activity. The antioxidant potential of the ethanol
extract was examined using a 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity, reducing power, hydroxyl radical scavenging activity, nitric
oxide radical scavenging activity and hydrogen peroxide radical scavenging activity. The extract had significant dose-dependent antioxidant activity in all in
vitro experiments. Hepatoprotective activity of the extract was evaluated in rat model of carbon tetrachloride (CCl4) induced liver damage. CCl4 significantly
altered serum marker enzymes and total protein. The ethanol extract of Piper cubeba attenuated CCl4 induced serum marker enzymes and total protein. Histology of liver
sections of the animals treated with the extracts showed the presence of normal hepatic cords, absence of necrosis and fatty infiltration which further evidence the
hepatoprotective activity.
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Keywords
Piper cubeba, CCL4, antioxidant, hepatoprotective activity
Citation
Pachpute Amol P, Deshmukh Tushar A. Antioxidant and hepatoprotective activity of an ethanol extract of piper cubeba fruits. International Journal of Research and Development in Pharmacy and Life Sciences. 2013 Feb-Mar; 2(2): 321-329.