Preformulations studies and preperation of dithranol loaded solid lipid nanoparticles.

Khan, Shagufta; Tiwari, Tripti; Tyagi, Shweta; Bhowmik, Mithun; Joshi, Amit; Dubey, Balkrishna

Preformulations studies and preperation of dithranol loaded solid lipid nanoparticles.

Date

2012-10

Authors

Khan, Shagufta

Tiwari, Tripti

Tyagi, Shweta

Bhowmik, Mithun

Joshi, Amit

Dubey, Balkrishna

Abstract

Dithranol belongs to the keratolytic category, which is widely used drug in the treatment of psoriasis. The drug is practically insoluble in water. Many conventional dosage forms for psoriasis treatment have been have been formulated earlier, but they did not show good results. Hence in the present study, it was attempted to formulate dithranol in the form of solid lipid nanoparticle. Solid lipid nanoparticles of dithranol were obtained by adaption of lipid dispersion method. Preformulation studies were performed to check the compatibility of drug and excepient for the preparation of formulation by DSC and no interaction was found. Solubility study, partition coefficient determination, UV analysis, HPLC study, FTIR study were also performed. After the preformulation studies Dithranol loaded solid lipid nanoparticles was also prepared. Hence it was concluded that solid lipid nanoparticle of dithranol could be formulated.

Keywords

dithranol, psoriasis, solid lipid nanoparticle, preformulation studies

Citation

Khan Shagufta, Tiwari Tripti, Tyagi Shweta, Bhowmik Mithun, Joshi Amit, Dubey Balkrishna. Preformulations studies and preperation of dithranol loaded solid lipid nanoparticles. International Journal of Research and Development in Pharmacy and Life Sciences. 2012 Oct-Nov; 1(4): 183-188.