Preformulations studies and preperation of dithranol loaded solid lipid nanoparticles.
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Date
2012-10
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Abstract
Dithranol belongs to the keratolytic category, which is widely used drug in the treatment of psoriasis. The drug is practically insoluble in water. Many
conventional dosage forms for psoriasis treatment have been have been formulated earlier, but they did not show good results. Hence in the present study, it was
attempted to formulate dithranol in the form of solid lipid nanoparticle. Solid lipid nanoparticles of dithranol were obtained by adaption of lipid dispersion
method. Preformulation studies were performed to check the compatibility of drug and excepient for the preparation of formulation by DSC and no interaction was
found. Solubility study, partition coefficient determination, UV analysis, HPLC study, FTIR study were also performed. After the preformulation studies Dithranol
loaded solid lipid nanoparticles was also prepared. Hence it was concluded that solid lipid nanoparticle of dithranol could be formulated.
Description
Keywords
dithranol, psoriasis, solid lipid nanoparticle, preformulation studies
Citation
Khan Shagufta, Tiwari Tripti, Tyagi Shweta, Bhowmik Mithun, Joshi Amit, Dubey Balkrishna. Preformulations studies and preperation of dithranol loaded solid lipid nanoparticles. International Journal of Research and Development in Pharmacy and Life Sciences. 2012 Oct-Nov; 1(4): 183-188.