Therapeutic drug monitoring in psychiatry: An important step in clinical practice.
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Date
2012-10
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Abstract
TDM in psychiatry is a tool to optimize the therapeutic regimens in clinical practice. Psychopharmacology encompasses
those drugs which metabolize and their metabolites also are active in the body. CYP-450 of antipsychotics is unique as the drugs
are lipid soluble and the heterogeneous class of drugs act on different types of receptors and produce variable responses. Various
techniques are involved to estimate the drug levels of those drugs. HPLC is a golden standard to assay the serum drug
concentration of these drugs. The metabolites can also be assayed along with the parent drug. TDM of these drugs if applied at
tertiary care, individualization of dosage regime of these drugs can help the outcomes of therapy and even drug-drug interaction
can display the PK/PD nature of such drugs.
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Keywords
TDM, PK/PD, ICD, DSM-IV, CYP, PM, CYP3A4, CYP2C19
Citation
Loan G M, Wafai Z A, Qadrie Z L, Zargar S A. Therapeutic drug monitoring in psychiatry: An important step in clinical practice. International Journal of Research and Development in Pharmacy and Life Sciences. 2012 Oct-Nov; 1(4): 176-182.