Effects of curcumin on the gastric emptying of albino rats.
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Date
2012-04
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Abstract
Curcumin (diferuloylmethane), a polyphenol, is an active
principle of the perennial herb Curcuma longa commonly known as
turmeric. Turmeric (CURCUMA LONGA L.) is a medicinal plant extensively
used in Ayurveda, Unani, and Siddha medicine as a home remedy for
various diseases including biliary diseases, cough, hepatic diseases, wound
healing. However studies on the effect of curcumin on the gastric emptying
are nearly nonexistent. It is hypothesized that curcumin may have an
effect on gastric emptying. For this reason the present study was aimed to
study the effect of curcumin on gastric emptying. Rats were divided into
5 groups (Group I – Group V), based on the time interval between
administration of curcumin/vehicular fluid to administration of barium
sulphate (Group I – 1 hr, Group II – 8 hrs, Group III – 16 hrs, Group IV –
24 hrs, Group V – 48 hrs). Each group was further divided into two subgroups,
Group A (control) and Group B (experimental), containing 6 rats
each. Rats in experimental group were administered curcumin
intragastrically, in the dose of 1 gm/kg body weight, suspended in normal
saline (0.9% NaCl). The controls were given vehicular fluid intragastrically,
in volume equal to the experimental animals. It was observed that there
was a decrease in the gastric emptying in all the experimental groups.
Description
Keywords
gastric emptying, curcumin, barium sulphate
Citation
Purwar Brijesh, Shrivastava Abha, Arora Neetu, Kumar Anil, Saxena Yogesh. Effects of curcumin on the gastric emptying of albino rats. Indian Journal of Physiology and Pharmacology. 2012 Apr-Jun; 56(2): 168-173.