Effect of garlic (allium sativum) on hematology and erythrocyte antioxidant defense system of albino rats exposed to heavy metals (nickel II & chromium VI).
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Date
2012-04
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Abstract
Heavy metals are stable environmental contaminants, causing
various alterations in target tissues. Garlic has some beneficial effect in
preventing heavy metal induced various alteration. The objective was to
investigate the possible protective role of fresh aqueous homogenate of
garlic on hematology, erythrocyte antioxidant defense system in male albino
rats treated with NiSO4 and K2Cr2O7. Rats were divided into six groups.
Group I was untreated control. Group II was given aqueous homogenate
of garlic (orally). Group III was administered with nickel sulfate (i.p).
Group IV was given NiSO4 and garlic simultaneously. Group V was
administered with K2Cr2O7 (i.p). Group VI were treated simultaneously with
K2Cr2O7 and garlic. RBC, WBC, platelet count, PCV%, hemoglobin
concentration decreased significantly and clotting time increased significantly
after nickel treatment. After chromium treatment all the values decreased
except clotting time. Increased malondialdehyde and glutathione level after
nickel and chromium treatment was observed. Also erythrocyte superoxide
dismutase, glutathione peroxidase and catalase activities significantly
increased after nickel and chromium treatment. Simultaneous garlic
supplementation exhibited protective role to combat nickel toxicity, whereas
no such beneficial effects were observed for chromium (VI). Garlic may
partially prevent nickel and chromium induced alteration but such
ameliorated effects as an antioxidant is only restricted on nickel induced
alteration.
Description
Keywords
allium sativum, nickel II, chromium VI, hematology, erythrocyte antioxidant defense
Citation
Tikare Swati N, Yendigeri Saeed, Gupta Amrita Das, Dhundasi Salim A, Das Kusal K. Effect of garlic (allium sativum) on hematology and erythrocyte antioxidant defense system of albino rats exposed to heavy metals (nickel II & chromium VI). Indian Journal of Physiology and Pharmacology. 2012 Apr-Jun; 56(2): 137-146.