Inflammation and oxidative stress in hypothyroids: Additive effects on cardiovascular risk.
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Date
2011-10
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Abstract
Cardiovascular disease is one of the major complications of
hypothyroidism which is one of the most common endocrine disorders in
India. In the present study, we have analyzed the link among oxidative
stress, C reactive protein which is an inflammatory marker and the
cardiovascular lipid risk factors in hypothyroid patients which has not been
analyzed before. Sixty seven untreated hypothyroid patients were recruited
consecutively for the study. Their ultrasensitive C reactive protein level
and oxidative stress profile were measured apart from various lipid risk
factors of cardiovascular disease. Ultra sensitive C reactive protein was
significantly correlated with increased lipid risk factors of cardiovascular
disease, thyroid stimulating hormone level and indices of oxidative stress
in these patients. Low grade inflammation in hypothyroidism plausibly acts
as the link between higher oxidative stress and the underlying
cardiovascular risk among hypothyroid patients.
Description
Keywords
ultrasensitive C reactive protein, oxidative stress, hypothyroidism, cardiovascular risk
Citation
Nanda Nivedita, Bobby Zachariah, Hamide Abdoul. Inflammation and oxidative stress in hypothyroids: Additive effects on cardiovascular risk. Indian Journal of Physiology and Pharmacology. 2011 Oct-Dec; 55(4): 351-356.