Variation in response to experimental pain across the menstrual cycle in women compared with one month respose in men.
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Date
2010-01
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Abstract
Gender differences in pain perception have been reported in
literature. However, most such studies have ignored the role of female sex
hormones in influencing pain response across menstrual cycle (MC). In this
study, we have investigated the variation in pain response on different days
of the menstrual cycle. Ninety subjects (60 females) were subjected to
experimental pain of cold pressor task, on days 1, 7, 14, and 21 of the MC
(females), and on four consecutive Mondays of a month (males). Male subjects
showed no variation in pain response. Females reported higher pain sensitivity
on days 7 and 14 of MC. We suggest that experimental pain studies involving
female menstruating subjects should be carried out only during a particular
phase of the cycle, and this phase should be reported in literature to increase
the reproducibility of the experiment.
Description
Keywords
Cold pressor task, experimental pain, menstrual cycle, pain response
Citation
Kumar Manoj, Narayan Jagdish, Verma Nar Singh, Saxena Indu. Variation in response to experimental pain across the menstrual cycle in women compared with one month respose in men. Indian Journal of Physiology and Pharmacology. 2010 Jan-Mar; 54(1): 57-62.