Oxidative stress and low dose ionizing radiation.
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Date
2009-04
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Abstract
The field of radiation biochemistry has provided tremendous
impact in recent years as extensive research on free radicals has implicated
them in radiation damage. An important offshoot of this field is the branch
dealing with radiological protection in medical applications like diagnostic
radiology. Hence, we decided to investigate the relationship between
oxidative stress and low dose ionizing radiation (x-rays) in the work
environment of x-ray technicians (radiographers), by comparing their RBC
malondialdehyde, % hemolysis, catalase and plasma vitamin E levels with
those of controls. There was a significant increase in the susceptibility of
RBCs to hemolysis in radiographers compared to controls. Malondialdehyde
and catalase levels were slightly increased in the radiographers, but this
did not disturb the steady state concentration of their plasma vitamin E.
These findings go in favour of theories stating that exposure to low dose
ionizing radiation does cause a greater amount of oxidative stress, than
that caused during normal routine metabolic processes.
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Keywords
X-rays, radiographers, oxidative stress
Citation
Puthran Shilpa S, Sudha K, Rao Gayathri M, Shetty Beena V. Oxidative stress and low dose ionizing radiation. Indian Journal of Physiology and Pharmacology. 2009 Apr-June; 53(2): 181-184.