Obesity attenuates formalin-induced tonic pain in British Angora Rabbits.
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Date
2009-01
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Abstract
Obesity is known to alter various physiological parameters
including the pain sensitivity. There are conflicting reports on the pain
sensitivity in obesity. In this context, the present study was aimed to
investigate the tonic pain response in obese rabbit model. To achieve this
aim, two groups of adult male British Angora rabbits were used. One of the
groups was fed with standard rabbit chow and served as control. The other
group was fed high fat diet (HFD) for 10 weeks to produce obesity. The
standard formalin test was performed at the start and after 10 weeks of
dietary regimen in both the groups. Timed behavioral responses (limping,
elevation of paw, licking, biting, grooming etc.) were categorized and
quantified with the help of standard pain rating scale. The total average
pain rating score decreased significantly from 2.01 ± 0.02 to 1.47 ± 0.08
(P<0.05) in HFD group after 10 weeks of dietary regimen, whereas there
was no change in the control group. A significant negative correlation was
observed between body weight and pain rating score in HFD group of
rabbits (P<0.05, r=–0.62). Results suggest that obesity attenuates the tonic
pain responses induced by formalin in British Angora rabbits.
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Keywords
obesity, British Angora rabbit, tonic pain, formalin tests
Citation
Sinha R, Dhungel S, Sinha M, Paudel B H, Bhattacharya N, Mandal M B. Obesity attenuates formalin-induced tonic pain in British Angora Rabbits. Indian Journal of Physiology and Pharmacology. 2009 Jan-Mar; 53(1): 83-87.