Comparison of effects of olanzapine and risperidone on body mass index and blood sugar level in schizophrenic patients.
Loading...
Date
2009-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Schizophrenia is one of the most debilitating disorders with
devastating effects on its victims and their families. Atypical antipsychotics
(AAPs) because of their superior efficacy, reduced side effects, & better
compliance, have rapidly become the mainstay of treatment. But, because
of paucity of research & literature on the long-term metabolic side effect
profile of these AAPs in Indian setup, this prospective study has been
carried out to compare the effects of olanzapine & risperidone on body
weight, body mass index, & blood sugar level in schizophrenic patients.
Among 60 newly diagnosed DSM-IV patients of schizophrenia enrolled,
it was observed that mean body weight & BMI were significantly increased
from baseline to 6 & 12 weeks in both olanzapine (n=30) & risperidone
groups (n=30) (P<0.001). Also, mean blood sugar was found to be significantly
elevated after 6 & 12 weeks of treatment with olanzapine (P<0.001) but not
in risperidone group.
Thus, the present study underscores the need for baseline and six
weekly monitoring of body weight and blood glucose in routine clinical
practice with AAPs.
Description
Keywords
Schizophrenia, olanzapine, risperidone, body mass index, blood sugar
Citation
Ingole Shahu, Belorkar N R, Waradkar Praveer, Shrivastava Meena. Comparison of effects of olanzapine and risperidone on body mass index and blood sugar level in schizophrenic patients. Indian Journal of Physiology and Pharmacology. 2009 Jan-Mar; 53(1): 47-54.