Effect of surgical stress on neutrophil function.
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Date
2008-07
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Abstract
The present study was undertaken to find out the effect of
surgical stress on nonspecific immune response. Twenty patients posted for
various elective surgeries participated in the study (male : 17, female : 3,
age : 43.4±2 yrs). The blood samples were taken preoperatively (4 to 6 days
prior to surgery) and the following parameters were assessed: phagocytic
index of neutrophils, avidity index of neutrophils and percentage of
neutrophils in differential count. These were compared with the respective
parameters assessed in the blood samples taken 24 hours after surgery.
There was a significant (P=0.0001) decrease in the phagocytic index of
neutrophil and a significant (P=0.003) increase in the percentage of
neutrophils in differential count in the postoperative blood samples.
However, the avidity index did not show a significant change. It could be
tentatively concluded that surgical stress causes depression of nonspecific
immunity in the early postoperative period.
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Keywords
surgical stress, immune response, neutrophil function, phagocytic index, avidity index, differential neutrophil count
Citation
Savitha D, Rao K Raghavendra, Girish S P. Effect of surgical stress on neutrophil function. Indian Journal of Physiology and Pharmacology. 2008 Jul-Sept; 52(3): 302-306.