Levels of malondialdehyde and antioxidants in the blood of patients with vitiligo of age group 11–20 years.
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Date
2008-07
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Abstract
The aetiopathogenesis of vitiligo has not been fully understood.
To investigate the role of oxidative stress in pathogenesis of vitiligo, we
examined the blood level of antioxidants and malondialdehyde in 40 patients
with generalized vitiligo and 40 healthy volunteers belonging to same age
group. Our results revealed that the level of malondialdehyde was
significantly raised while those of vitamin E, uric acid and ceruloplasmin
were significantly lowered (P<0.05) in patients with generalized vitiligo as
compared to controls. This demonstrates the presence of an imbalance in
the oxidant-antioxidant system in the blood of vitiligo patients and thus
provides support for a free radical mediated damage as a pathogenic event
in vitiligo.
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Keywords
free radicals, malondialdehyde, vitamin E, uric acid, ceruloplasmin, antioxidants
Citation
Jain D, Misra R, Kumar A, Jaiswal G. Levels of malondialdehyde and antioxidants in the blood of patients with vitiligo of age group 11–20 years. Indian Journal of Physiology and Pharmacology. 2008 Jul-Sept; 52(3): 297-301.