Effect of methylene blue on oxidative stress and antioxidant defence parameters of rat hepatic and renal tissues.
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Date
2008-07
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Abstract
The objective of the present study was to investigate the effect
of administration of 1 mM methylene blue (MB) in drinking water for 30
days on hepatic and renal antioxidant status in female adult Wistar strain
rats (n=5). MB failed to induce significant change in any of the measured
antioxidant defence parameters namely, superoxide dismutase (SOD),
catalase (CAT) and reduced glutathione (GSH). However, a marginally
significant (P<0.05) increase in the level of lipid peroxidation (LPx) was
recorded in liver, while a reduction (P<0.05) in its level in the kidney was
noticed. Serum alanine amino transferase (AlaAT) and creatinine levels
significantly (P<0.001) decreased in MB treated rats without any change in
blood urea nitrogen (BUN) level. Our findings suggest that the effect of
MB as administered in the present study was tissue specific with regard to
the level of LPx, however, in general, it does not impair liver and kidney
functions as evidenced by serum parameters.
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Keywords
methylene blue (MB), oxidative stress (OS), superoxide dismutasea (SOD), catalase (CAT), reduced glutathione (GSH), lipid peroxidation (LPx), alanine amino transferase (AlaAT), blood urea nitrogen (BUN), creatinine
Citation
Jena Srikanta, Chainy Gagan B N. Effect of methylene blue on oxidative stress and antioxidant defence parameters of rat hepatic and renal tissues. Indian Journal of Physiology and Pharmacology. 2008 Jul-Sept; 52(3): 293-296.