A novel 11;18 translocation in a case of acute myeloid leukemia with maturation.
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Date
2012-09
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Abstract
Acute myeloid leukemia with maturation (AML-M2) is associated with the 8;21 translocation. For the first time in an adult patient with AML-M2, a novel unbalanced translocation involving the short arm of chromosome 11 and long arm of chromosome18 with new breakpoints is presented. CD82 on band 11p11.2 and GATA 6 on 18q11.2 may play a role in the pathogenesis of de novo AML M2. The report with translocation (11;18)(p11.2;q11.2), as the sole cytogenetic abnormality provides more data on the leukemogenesis of de novo AML M2.
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Keywords
Acute myeloid leukemia with maturation 2, CD82, chromosomal abnormality, GATA6, immunophenotyping, translocation 11;18
Citation
Devi G Sandhya, Ahmed Faiq, Khadke Kavita, Murthy Sudha S, Rajappa Senthil J. A novel 11;18 translocation in a case of acute myeloid leukemia with maturation. Indian Journal of Human Genetics. 2012 Sept; 18(3): 369-372.