Immuno-localization of glucose transporter 4 in healthy human gingiva.
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Date
2012-09
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Abstract
Background: The gingiva has been shown to be a target tissue for several hormones. Insulin induces uptake of glucose in the peripheral tissues by upregulating the Glucose transporter 4 expression. Little information is available on the expression of Glucose transporter 4 in human gingiva.
Aim: In this regard, a pilot study was performed with the aim of determining the distribution pattern of Glucose transporter 4 in healthy human gingiva.
Materials and Methods: Immuno-histochemistry was performed on 10 mounted sections of healthy human gingiva with the primary antibody Glucose Transporter 4 (GLUT 4). Appropriate positive and negative controls were used.
Results: Glucose transporter 4 expression was observed in the basal and suprabasal layers of the gingival epithelium and fibroblasts of the gingival connective tissue.
Conclusion: This may be the first study to demonstrate the expression of GLUT 4 in the healthy human gingiva. The results of this study raise the possibility that gingiva may serve as a target tissue for insulin action.
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Keywords
Glucose metabolism, glucose transporter 4, human gingiva
Citation
Rao Suresh Ranga, Sundaram Sandhya, Lavu Vamsi. Immuno-localization of glucose transporter 4 in healthy human gingiva. Indian Journal of Dental Research. 2012 Sept-Oct; 23(5): 565-567.