Pharmacological efficacy of argemone mexicana plant extract, against cysteamine-induced duodenal ulceration in rats.
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Date
2011-03
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Abstract
Objective: The plant Argemone mexicana is traditionally used as diuretic, anti-inflammatory, antibacterial, antifungal agent, and has wound-healing property. This study was carried out to evaluate the effect of A. mexicana aerial part of the plant (methanolic and aqueous extract p.o.) on duodenal ulceration. Materials and Methods: The study was carried out on the duodenal ulceration model by using cysteamine hydrochloride. Ranitidine (20 mg/kg) was used as standard drug. Results: Both the extracts of the plant A. mexicana produced a significant activity in cysteamine-induced duodenal ulceration. The aqueous extract at the dose-dependent manner showed the potent activity than methanolic extract. Conclusion: The plant A. mexicana Linn. Increased healing of gastric ulceration and prevented the development of experimentally induced duodenal ulceration in rats.
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Keywords
Argemone mexicana, cysteamine, duodenal ulcer, ranitidine, Wistar rats
Citation
Das Prabhat K, Pillai Sujit, Kar Durga, Pradhan Debasish, Sahoo Sabuj. Pharmacological efficacy of argemone mexicana plant extract, against cysteamine-induced duodenal ulceration in rats. Indian Journal of Medical Sciences. 2011 Mar; 65(3) 92-99.