Ceftriaxone resistant Shigella Flexneri, an emerging problem.
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Date
2010-12
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Abstract
Shigellosis is a disease of public health importance in developing countries. It may cause self-limited diarrhea to severe dysentery. Emergence of multi drug resistant (MDR) strains is a growing concern globally. Ceftriaxone and ciprofloxacin are the drugs of choice for MDR cases. Here, we report a case of MDR Shigella flexneri from an immunocompromised patient. The strain was resistant to ceftriaxone [minimum inhibitory concentration (MIC) ≥ 64 μg/ml], limiting the treatment option. Simultaneously, the strain was also found to be resistant to ciprofloxacin (MIC ≥ 4 μg/ml). However, it was susceptible to ceftazidime (MIC 4 μg/ml). This is the first case of ceftriaxone resistant Shigella spp. reported from our hospital.
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Keywords
Ceftriaxone, extended spectrum beta lactamase, minimum inhibitory concentration, multi drug resistant, Shigella flexneri
Citation
Gupta Soham, Mishra Baijayanti, Muralidharan Sethumadhavan, Srinivasa Hiresave. Ceftriaxone resistant Shigella Flexneri, an emerging problem. Indian Journal of Medical Sciences. 2010 Dec; 64(12) 556-559.