Fever of unknown origin in a patient of systemic onset juvenile idiopathic arthritis.
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Date
2010-07
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Abstract
Hemophagocytic lymphohistiocytosis is a potentially fatal condition characterized by pathologic immune activation, which can complicate infections, childhood systemic rheumatologic diseases and malignancies. Here we report a case of reactive hemophagocytic lymphohistiocytosis [macrophage activation syndrome] complicating systemic onset juvenile idiopathic arthritis, which was treated successfully with dexamethasone and cyclosporine. Reactive hemophagocytic lymphohistiocytosis or macrophage activation syndrome should be considered in patients of juvenile idiopathic arthritis with prolonged fever of unknown origin and cytopenias. Early diagnosis with high index of suspicion and prompt, aggressive treatment are needed for successful outcomes.
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Keywords
Fever of unknown origin, hemophagocytosis, juvenile idiopathic arthritis, macrophage activation
Citation
Vishwanath Vinod Kolar, Krishnamurthy Aishwarya, Karyampudi Arun, Dutta Tarun Kumar. Fever of unknown origin in a patient of systemic onset juvenile idiopathic arthritis. Indian Journal of Medical Sciences. 2010 July; 64(7). 333-336.