Neuropharmcological potential of methanolic extract and a triterpene isolated from Madhuca longifolia L leaves in mice.
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Date
2012-12
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Abstract
The methanolic extract of M. longifolia (MLME) and a compound a triterpene, derivative of madhucic acid (dMA) isolated from the leaves of M. longifolia, were investigated for their possible neuropharmacological activities in mice using phenobarbitone induced sleeping time, spontaneous motor activity, marble burying test and Eddy’s hot plate method. LD50 for MLME and dMA were 100 and 10 mg/kg of body weight, respectively. Both MLME and dMA (10 mg/kg and 2 mg/kg oral route respectively) exhibited significant increase in phenobarbitone induced sleeping time, greater reduction in spontaneous motor activity and marble burying activity, confirming their sedative nature. Both MLME and dMA also exhibited considerable antinociceptive activity in experimental animals. The results suggest that both MLME and dMA have CNS depressant activity in mice.
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Keywords
Chlorpromazine, Diazepam, Madhuca longifolia, Madhucic acid, Neuropharmacological effect, Phenobarbitone
Citation
Inganakal Triveni S, Ahmed Md Liyakhat, Swamy Paramjyothi. Neuropharmcological potential of methanolic extract and a triterpene isolated from Madhuca longifolia L leaves in mice. Indian Journal of Experimental Biology. 2012 Dec; 50(12): 862-866.